On the role of anesthesia on the body/brain temperature differential in rats
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چکیده
Different anesthetics often produce distinctly different effects on blood flow, oxygen consumption and other physiological parameters in animal studies. We investigated the influence of two common anesthetics—alpha-chloralose and chloral hydrate—on the body-core/brain temperature differential in rats. The results indicate a remarkable difference of 4.3470.64 1C (mean7SD) in the body-core/brain-cortical temperature differential observed under alphachloralose anesthesia compared to a relatively smaller differential of 2.7370.40 1C under chloral hydrate anesthesia in rats. Temperature gradients within the brain are around 0.3 1C/mm in both cases. Thus, the anesthetic utilized has the potential to markedly influence brain temperature and therefore other important physiological parameters in the brain. r 2004 Elsevier Ltd. All rights reserved.
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تاریخ انتشار 2004